Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients?

Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods. Migraine-attack plasma, bu...

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Bibliographic Details
Published in:	Journal of the neurological sciences Vol. 93; no. 1; p. 51
Main Authors:	Ferrari, M D, Odink, J, Frölich, M, Tapparelli, C, Portielje, J E
Format:	Journal Article
Language:	English
Published:	Netherlands 01-10-1989
Subjects:	Adult Blood Platelets - metabolism Enkephalin, Methionine - blood Female Humans Male Middle Aged Migraine Disorders - blood Serotonin - blood
Online Access:	Get more information
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Summary:	Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods. Migraine-attack plasma, but not migraine attack-free plasma, released Met-enkephalin from platelets of migraineurs. Platelets of healthy controls or tension headache sufferers did not release their Met-enkephalin in response to either incubation medium. In contrast to Met-enkephalin, serotonin was not released from platelets in relevant quantities by migraine-attack plasma.
ISSN:	0022-510X
DOI:	10.1016/0022-510X(89)90160-3