TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons

Highlights • Three distinct subclasses of sensory neurons mediate cold responses. • Cold responses in TRPA1-expressing neurons depend on TRPA1 and not TRPM8 channels. • Cold-sensitive TRPA1 neurons express more TRPA1 than cold-insensitive TRPA1 neurons. • KV 1.2 channels attenuate cold-sensitivity o...

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Bibliographic Details
Published in:	Neuroscience Vol. 353; pp. 76 - 86
Main Authors:	Memon, Tosifa, Chase, Kevin, Leavitt, Lee S, Olivera, Baldomero M, Teichert, Russell W
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 14-06-2017
Subjects:	cold pain ion channel KV1.2 Neurology pharmacology TRPA1 TRPM8 K V 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid TRPA1 cold pain voltage-gated potassium channel AITC dorsal-root ganglia ROI allyl isothiocyanate fetal bovine serum signal to noise K V1.2 TRP ion channel FBS HEPES SNR region of interest pharmacology DRG TRPM8 transient receptor potential channel KV1.2 KV
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Summary:	Highlights • Three distinct subclasses of sensory neurons mediate cold responses. • Cold responses in TRPA1-expressing neurons depend on TRPA1 and not TRPM8 channels. • Cold-sensitive TRPA1 neurons express more TRPA1 than cold-insensitive TRPA1 neurons. • KV 1.2 channels attenuate cold-sensitivity of TRPA1-expressing neurons.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2017.04.001