Assessment in Multisite Randomized Clinical Trials of Patients with Autistic Disorder: The Autism RUPP Network

• Published in: Journal of autism and developmental disorders Vol. 30; no. 2; pp. 99 - 111
• Main Authors: Arnold, L. Eugene, Aman, Michael G, Martin, Andres, Collier-Crespin, Angie, Vitiello, Benedetto, Tierney, Elaine, Asarnow, Robert, Bell-Bradshaw, Felicia, Freeman, Betty Jo, Gates-Ulanet, Patricia, Klin, Ami, McCracken, James T, McDougle, Christopher J, McGough, James J, Posey, David J, Scahill, Lawrence, Swiezy, Naomi B, Ritz, Louise, Volkmar, Fred
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01-04-2000
• Subjects: Algorithms; Assessment; Autism; Autistic people; Behavior Problems; Clinical Diagnosis; Clinical randomized controlled trials; Communication Problems; Evaluation Methods; Hyperactivity; Networks; Outcome Measures; Patients; Pediatrics; Performance Based Assessment; Pharmacology; Principals; Psychometrics; Psychopathology; Rating Scales; Research Methodology; Self Destructive Behavior; Standardized Tests; Treatment
• ISSN: 0162-3257; 1573-3432
• DOI: 10.1023/A:1005451304303

This paper explains how the Autism Research Units on Pediatric Psychopharmacology (RUPP Autism Network) resolved common assessment problems including communication problems compromising use of the patient as informant, broad subject heterogeneity, difficulties in assessing low-end IQs, scarcity of autism-adapted cognitive and neuropsychological tests, and reliability of the Autism Diagnostic Interview. (Contains extensive references.) (DB)