Semi-automated production of 89Zr-oxalate/89Zr-chloride and the potential of 89Zr-chloride in radiopharmaceutical compounding

• Published in: Applied radiation and isotopes Vol. 107; pp. 317 - 322
• Main Authors: Lin, Mai, Mukhopadhyay, Uday, Waligorski, Gregory J., Balatoni, Julius A., González-Lepera, Carlos
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-01-2016
• Subjects: 89Zr; Chemistry, Pharmaceutical - instrumentation; Chemistry, Pharmaceutical - methods; Chlorides - isolation & purification; Cyclotrons; Deferoxamine; DFO; Humans; Immunoglobulin G - isolation & purification; Isotope Labeling - instrumentation; Isotope Labeling - methods; Oxalates - isolation & purification; PET; Positron-Emission Tomography; Radioisotopes - isolation & purification; Radiopharmaceutical compounding; Radiopharmaceuticals - isolation & purification; Remote synthesis module; Semi-automation; Solid Phase Extraction; Zirconium - isolation & purification; 89Zr; Semi-automation; DFO; Radiopharmaceutical compounding; Remote synthesis module; PET; Zr
• ISSN: 0969-8043; 1872-9800
• DOI: 10.1016/j.apradiso.2015.11.016

Interest in using 89Zr is rapidly increasing for immuno-PET applications due to its unique characteristics and increased availability. The focus of this study was to develop an optimized semi-automated methodology for producing 89Zr-oxalate/89Zr-chloride, and evaluate the potential application of 89Zr-chloride for radiopharmaceutical compounding. The data presented herein will be useful for the production of 89Zr-labeled radiopharmaceuticals and their compliance with regulatory issues for both preclinical and clinical use.
•The optimized semi-automated strategy for 89Zr production was developed.•High effective specific activity of 89Zr-oxalate/89Zr-chloride was obtained.•The use of 89Zr-chloride in radiopharmaceutical compounding is proposed.