Study of (p,x) reactions in the natCaO targets

• Published in: Radiation physics and chemistry (Oxford, England : 1993) Vol. 207
• Main Authors: Anees Ahmed, Arshiya, Misiak, Ryszard, Bartyzel, Mirosław, Mietelski, Jerzy W., Wąs, Bogdan
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-06-2023
• Subjects: Proton induced reactions; Radionuclide production; Reaction cross section; Scandium; Theranostic; Radionuclide production; Proton induced reactions; Reaction cross section; Theranostic; Scandium
• ISSN: 0969-806X; 1879-0895
• DOI: 10.1016/j.radphyschem.2023.110821

The development of novel medical radioisotopes for diagnostic and therapeutic purposes is critical for the advancement of personalized nuclear medicine. Radio metals contain promising theranostic pairs and can be used to label proteins and peptides. Scandium radionuclides have recently gained a lot of attention for their radiation characteristics (such as half-life, β particle and gamma emission energies) in order to improve the efficiency of medical care or therapeutic benefit for specific groups of patients.
An accurate understanding of the production cross-sections is required to maximize the production yield and radionuclidic purity, as well as to improve the model predictions. In this paper, we report the measurement of the cross-section of (p,x) reactions for the production of 47Ca, 42K, 43K, and 44mSc, 46Sc, 47Sc, 48Sc using natCaO targets using proton beam of energy up to 60 MeV. The reported data for 47Sc is the first experimental data with a natCaO target in the 16–60 MeV energy range. All radioisotope cross sections produced by natCaO(p, x) reactions are compared to literature data and TALYS predictions.
•Proton induced reaction on natCaO using stack foil activation method.•Study of long-lived radioactive impurities in natCaO(p,x) reactions at 16–60 MeV proton energy range.•Comparison of experimental results with the available data base and TALYS.