Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P 1 agonists

• Published in: Bioorganic & medicinal chemistry letters Vol. 21; no. 19; pp. 6013 - 6018
• Main Authors: Buzard, Daniel, Han, Sangdon, Thoresen, Lars, Moody, Jeanne, Lopez, Luis, Kawasaki, Andrew, Schrader, Thomas, Sage, Carleton, Gao, Yinghong, Edwards, Jeff, Barden, Jeremy, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Liu, Ling, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Xing, Charles, Espinola, Sheryll, Jones, Robert M.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-10-2011
• Subjects: FTY720; Immunomodulators; S1P 1 agonist; Sphingosine-1 phosphate receptor; S1P 1 agonist; Sphingosine-1 phosphate receptor; Immunomodulators; FTY720
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2011.05.110

S1P
1 receptor driven lymphopenia has proven utility in the treatment of an array of autoimmune disease states. As a part of our efforts to develop potent and selective S1P
1 receptor agonists, we have identified a novel chemical series of 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acid S1P
1 receptor agonists.