ELECTROCONVULSIVE THERAPY (ECT) FOR THE MANAGEMENT OF NEUROLEPTIC MALIGNANT SYNDROME (NMS) IN ADULTS

• Published in: Pakistan Armed Forces medical journal Vol. 68; no. 3; pp. 445 - 449
• Main Authors: Liaqat, Jahanzeb, Javed, Muhammad Umar, Naseem, Arshad, Raja, Waseem, Wali, Waseem
• Format: Journal Article
• Language: English
• Published: Rawalpindi AsiaNet Pakistan (Pvt) Ltd 01-06-2018; Army Medical College Rawalpindi
• Subjects: Blood pressure; Coma; Dopamine; Drug dosages; Electroconvulsive therapy; Hyperthermia; Nervous system; Pneumonia; Psychiatry; Psychotropic drugs; Rawalpindi Pakistan
• ISSN: 0030-9648; 2411-8842

Objective: To determine the efficacy and safety of electroconvulsive therapy (ECT) for the management of neuroleptic malignant syndrome (NMS) in adults.Study Design: Open label, unblinded series.Place and Duration of Study: This study was carried out at the Department of Neurology, Military Hospital Rawalpindi, from Jan 2015 to Dec 2015.Material and Methods: All the patients with the diagnosis of NMS during the study period were included in the study. Consective non-probability sampling technique was used. Patients were divided into two groups; uncomplicated and complicated cases of NMS.Results: A total of nineteen patients were included in this pilot study. Out of all, thirteen (68.4%) were males and six (31.6%) were females. Mean age of the patients was 35.05 (SD 13.362) years. The drug classes causing NMS were antipsychotic medicines in 73.7% of patients and antiemetics in 26.3% of patients. Mean electroconvulsive therapy (ECT) sessions given were 6.16 (SD 2.062). Following treatment n=16 (84.2%) patients had complete recovery while n=3 (15.3%) patients died.Conclusion: In this small, open label, unblinded study ECT appears effective and safe in treating NMS in adults. Larger randomized studies will help to confirm data emerging from this preliminary study.