Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxidative phosphorylation, and an important suppressor...

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Bibliographic Details
Published in:	Zhongliu fangzhi yanjiu Vol. 51; no. 3; pp. 216 - 219
Main Authors:	Che, Xin, Hu, Zhen, Wang, Yonggang, Li, Yaoping
Format:	Journal Article
Language:	Chinese
Published:	Tianjin China Anti-Cancer Association 01-03-2024 Magazine House of Cancer Research on Prevention and Treatment
Subjects:	de novo pyrimidine biosynthesis dhodh inhibitor Dihydroorotate dehydrogenase Ferroptosis Flavin neoplasms Orotic acid Oxidative phosphorylation oxphos Phosphorylation Pyrimidines Synthesis Tumors
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Summary:	Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxidative phosphorylation, and an important suppressor of the ferroptosis pathway. This study investigates the influence of DHODH on the progression of malignant tumors, including its important role in the de novo synthesis of pyrimidine, oxidative phosphorylation, and ferroptosis. The objective is to present evidence that DHODH is a potential target for the clinical treatment of tumors.
ISSN:	1000-8578
DOI:	10.3971/j.issn.1000-8578.2024.23.1067