Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway

• Published in: Cells (Basel, Switzerland) Vol. 13; no. 12; p. 1027
• Main Authors: Ma, Zelong, Zhou, Faxiao, Jin, Hua, Wu, Xiaoming
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-06-2024; MDPI
• Subjects: Adenosine; Amino acids; Analysis; Angiogenesis; Animals; Cancer therapies; Cell growth; Chemokine CXCL12 - metabolism; Chemokines; CXCL12 protein; CXCL12/CXCR4/ACKR3 axis; CXCR4 protein; Cytokines; Humans; IL6; JAK2; Kinases; Ligands; Metastasis; Neoplasms - metabolism; Neoplasms - pathology; Phosphorylation; Proteins; Receptors, CXCR - genetics; Receptors, CXCR - metabolism; Receptors, CXCR4 - metabolism; Review; Signal Transduction; Stat3 protein; STAT3 signaling pathway; STAT3 Transcription Factor - metabolism; Stem cells; targeted therapy; Therapeutic targets; Tumors; Vascular endothelial growth factor; targeted therapy; CXCL12/CXCR4/ACKR3 axis; IL6; STAT3 signaling pathway; JAK2
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells13121027

The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple mechanisms, while the STAT3 pathway also regulates the expression of CXCL12. This review offers a thorough and systematic analysis of the reciprocal regulatory mechanisms between the CXCL12/CXCR4/ACKR3 signaling axis and the STAT3 signaling pathway in the context of diseases, particularly tumors. It explores the potential clinical applications in tumor treatment, highlighting possible therapeutic targets and novel strategies for targeted tumor therapy.