Role of viruses in renal cell carcinoma

• Published in: Saudi journal of kidney diseases and transplantation Vol. 23; no. 1; pp. 53 - 57
• Main Authors: Salehipoor, Mahdi, Khezri, Abd al-Aziz, Behbahani, Abbas Behzad, Gerami zadah, Bita, Rahsaz, Murjan, Aghdaie, Mahdukht Husayn, Afrasiabi, Muhammad Amin
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 2012; Medknow Publications and Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adult; Aged; Aged, 80 and over; BK Virus - genetics; BK Virus - isolation & purification; Cancer; Carcinoma, Renal cell; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - virology; Case-Control Studies; Complications and side effects; Diagnosis; DNA, Viral - isolation & purification; Epstein-Barr Virus Infections - complications; Epstein-Barr Virus Infections - virology; Etiology; Female; Herpesvirus 4, Human - genetics; Herpesvirus 4, Human - isolation & purification; Human papillomavirus 16 - genetics; Human papillomavirus 16 - isolation & purification; Human papillomavirus 18 - genetics; Human papillomavirus 18 - isolation & purification; Humans; Iran; JC Virus - genetics; JC Virus - isolation & purification; Kidney Neoplasms - pathology; Kidney Neoplasms - virology; Kidneys; Male; Middle Aged; Papillomavirus Infections - complications; Papillomavirus Infections - virology; Polymerase Chain Reaction; Polyomavirus Infections - complications; Polyomavirus Infections - virology; Renal cell carcinoma; Risk Factors; Virus diseases; التشخيص; السرطان; الفيروسات; الكلى; المرضى; علم الأمراض; مسببات الأمراض; Iran; Saudi Arabia
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.91301

To determine whether viral infections are related to renal cell carcinoma (RCC), we studied 49 patients with RCC (29 patients were males with age ranging from 30 to 81 years and a mean of 57.5 years ; 20 patients were females with age ranging from 36 to 70 years with a mean of 58.4 years) and 16 non-neoplastic kidney patients as controls. Tissues specimens from study patients and controls were examined by nested polymerase chain reaction (PCR) to determine the presence of DNA of several viruses including human papilloma virus (HPV), Epstein–Barr virus (EBV), and polyoma viruses (BKV and JCV). Our results revealed that 7 of 49 (14.29 %) RCC tissue specimens had HPV DNA compared with none of 16 non-cancer control subjects. Regarding the HPV types, all the positive results were high-risk HPV types (type 16 in three and 18 in four patients). The present study suggests that HPV infection, especially high-risk types, is associated with RCC. However, more studies are necessary to demonstrate the molecular monogenic processes involved in this association.