The Immune Response of Cancer Cells in Breast and Gynecologic Neoplasms

• Published in: International journal of molecular sciences Vol. 25; no. 11; p. 6206
• Main Authors: Rakoczy, Katarzyna, Kaczor, Justyna, Sołtyk, Adam, Szymańska, Natalia, Stecko, Jakub, Drąg-Zalesińska, Małgorzata, Kulbacka, Julita
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-06-2024; MDPI
• Subjects: Animals; Breast cancer; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Cancer cells; Cancer therapies; Chemokines; Dendritic cells; Development and progression; Extracellular matrix; Female; Genital Neoplasms, Female - immunology; Genital Neoplasms, Female - pathology; Genotype & phenotype; Gynecological cancer; gynecological cancers; Gynecology; Humans; immune response; Medical prognosis; Medical research; Metabolism; Metabolites; Ovarian cancer; Panitumumab; Phosphorylation; Review; tumor microenvironment; Tumor Microenvironment - immunology; Tumors; Canada; breast cancer; tumor microenvironment; gynecological cancers; immune response
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25116206

Cancer diseases constitute a major health problem which leads to the death of millions of people annually. They are unique among other diseases because cancer cells can perfectly adapt to the environment that they create themselves. This environment is usually highly hostile and for normal cells it would be hugely difficult to survive, however neoplastic cells not only can survive but also manage to proliferate. One of the reasons is that they can alter immunological pathways which allow them to be flexible and change their phenotype to the one needed in specific conditions. The aim of this paper is to describe some of these immunological pathways that play significant roles in gynecologic neoplasms as well as review recent research in this field. It is of high importance to possess extensive knowledge about these processes, as greater understanding leads to creating more specialized therapies which may prove highly effective in the future.