A better prediction of progression‐free survival in diffuse large B‐cell lymphoma by a prognostic model consisting of baseline TLG and %ΔSUVmax

• Published in: Cancer medicine (Malden, MA) Vol. 8; no. 11; pp. 5137 - 5147
• Main Authors: Zhang, Yi‐Yang, Song, Le, Zhao, Mei‐Xin, Hu, Kai
• Format: Journal Article
• Language: English
• Published: Hoboken John Wiley and Sons Inc 01-09-2019; Wiley
• Subjects: Clinical Cancer Research; diffuse large B‐cell lymphoma; metabolic tumor volume; Original Research; prognostic model; total lesion glycolysis
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.2284

In the era of rituximab, the International Prognostic Index (IPI) has been inefficient in initial risk stratification for patients with R‐CHOP‐treated diffuse large B‐cell lymphoma (DLBCL). To estimate the predictive values of PET/CT quantitative parameters and three prognostic models consisting of baseline and interim parameters for three‐year progression‐free survival (PFS), we conducted an analysis of 85 patients in China with DLBCL underwent baseline and interim PET/CT scans and treated at the Department of Hematology of Peking University Third Hospital from November 2012 to November 2017. The PET/CT parameters, viz. the baseline and interim values of standardized uptake value (SUVmax), total metabolic tumor volume (TMTV), and total lesion glycolysis (TLG), and their rates of change, were analyzed by a receiver operating characteristics curve, Kaplan‐Meier analysis, and log‐rank test. Besides, the National Comprehensive Cancer Network International Prognostic Index (NCCN‐IPI) was also included in the multivariate Cox hazards model. Owing to the strong correlation between TMTV and TLG at baseline and interim (Pearson's correlation coefficient, r = 0.823, P‐value = 0.000, and 0.988, P‐value = 0.000, respectively), only TLG was included in the multivariate Cox hazards model, where TLG0 > 1036.61 g and %ΔSUVmax < 86.02% showed predictive value independently (HR = 10.42, 95% CI 2.35‐46.30, P = 0.002, and HR = 4.86, 95% CI 1.27‐18.54, P = 0.021, respectively). Replacing TLG in the equation, TMTV0 and TMTV1 both showed significantly predictive abilities like TLG (HR = 8.22, 95% CI 1.86‐32.24, P = 0.005, and HR = 2.96, 95% CI 1.16‐7.54, P = 0.023, respectively). After dichotomy, NCCN‐IPI also gave a significant performance (P = 0.035 and P = 0.010, respectively, in TLG and TMTV models). The baseline variables, that is, TMTV0, TLG0 and dichotomized NCCN‐IPI, and the interim variables TMTV1 and %ΔSUVmax, presented independent prognostic value for PFS. In prognostic model 2 (TLG0 + %ΔSUVmax), the group with TLG0 > 1036.61 g and %ΔSUVmax < 86.02% recognized 19 (82.6%) of the relapse or progression events, which showed the best screening ability among three models consisting of baseline and interim PET/CT parameters.
This is a study about 85 patients in China diagnosed with diffuse large B‐cell lymphoma and undergoing baseline and interim PET/CT scans concluding that baseline variables of PET/CT, MTV0, TLG0, and dichotomous National Comprehensive Cancer Network International Prognostic Index, and interim variables MTV1 and %ΔSUVmax presented independent prognostic value for progression‐free survival. A prognostic model consisting of TLG0 and %ΔSUVmax showed satisfactory screening ability.