Democratizing Microreactor Technology for Accelerated Discoveries in Chemistry and Materials Research

• Published in: Micromachines (Basel) Vol. 15; no. 9; p. 1064
• Main Authors: Sato, Tomomi, Masuda, Koji, Sano, Chikako, Matsumoto, Keiji, Numata, Hidetoshi, Munetoh, Seiji, Kasama, Toshihiro, Miyake, Ryo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23-08-2024; MDPI
• Subjects: accelerated discovery; Accelerators; advanced integrated microreactor development platform; Artificial intelligence; Automation; Batch processing; Chemical reactions; Chemical synthesis; Chemistry; Computational linguistics; Democratization; flow chemistry; Hypotheses; Language processing; Machine learning; Materials research; Microfluidics; microreactor; Microreactors; Natural language interfaces; Platforms; Product development; Review; advanced integrated microreactor development platform; machine learning; accelerated discovery; microreactor; artificial intelligence; flow chemistry
• ISSN: 2072-666X; 2072-666X
• DOI: 10.3390/mi15091064

Microreactor technologies have emerged as versatile platforms with the potential to revolutionize chemistry and materials research, offering sustainable solutions to global challenges in environmental and health domains. This survey paper provides an in-depth review of recent advancements in microreactor technologies, focusing on their role in facilitating accelerated discoveries in chemistry and materials. Specifically, we examine the convergence of microfluidics with machine intelligence and automation, enabling the exploitation of the cyber-physical environment as a highly integrated experimentation platform for rapid scientific discovery and process development. We investigate the applicability and limitations of microreactor-enabled discovery accelerators in various chemistry and materials contexts. Despite their tremendous potential, the integration of machine intelligence and automation into microreactor-based experiments presents challenges in establishing fully integrated, automated, and intelligent systems. These challenges can hinder the broader adoption of microreactor technologies within the research community. To address this, we review emerging technologies that can help lower barriers and facilitate the implementation of microreactor-enabled discovery accelerators. Lastly, we provide our perspective on future research directions for democratizing microreactor technologies, with the aim of accelerating scientific discoveries and promoting widespread adoption of these transformative platforms.