Autonomic Dysfunction and Cardiac Performance in Pregnant Women with Hypertensive Disorders: A Comparative Study Using Heart Rate Variability and Global Longitudinal Strain

• Published in: Life (Basel, Switzerland) Vol. 14; no. 8; p. 1039
• Main Authors: Bogdan, Carina, Apostol, Adrian, Ivan, Viviana Mihaela, Sandu, Oana Elena, Petre, Ion, Petre, Izabella, Marc, Luciana-Elena, Maralescu, Felix-Mihai, Lighezan, Daniel Florin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20-08-2024; MDPI
• Subjects: autonomic dysfunction; Autonomic nervous system; Blood pressure; cardiac performance; Cardiology; Cardiovascular disease; Cardiovascular system; Comparative studies; Disorders; Dysautonomia; Echocardiography; Fetuses; Fourier transforms; global longitudinal strain; Heart diseases; Heart rate; heart rate variability; Hypertension; hypertensive disorders of pregnancy; Medical history; Morbidity; Mortality; Nervous system; Parameters; Patients; Performance evaluation; Pre-eclampsia; preeclampsia; Pregnancy; Pregnancy complications; Software; Strain analysis; Subgroups; Tracking; Womens health; global longitudinal strain; preeclampsia; heart rate variability; autonomic dysfunction; hypertensive disorders of pregnancy; cardiac performance
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life14081039

(1) Background: Pregnancy induces significant physiological adaptations with substantial impacts on the cardiovascular system. Hypertensive disorders of pregnancy (HDPs) are connected to significant risks of maternal and fetal complications, contributing significantly to morbidity and mortality across the globe. This study focuses on evaluating autonomic dysfunction by analyzing heart rate variability (HRV) and assessing cardiac performance through global longitudinal strain (GLS) using speckle tracking echocardiography, as well as examining diastolic function in pregnant women with HDP compared to healthy pregnant controls. (2) Methods: A case-control study was conducted involving pregnant women diagnosed with gestational hypertension (GH), preeclampsia (PE), or severe preeclampsia (SPE) as the case group, and healthy pregnant women as the control group. HRV was measured to evaluate autonomic function, GLS was assessed using speckle tracking echocardiography, and diastolic function was evaluated through standard echocardiographic parameters. Data were analyzed to compare cardiac performance and autonomic regulation between the HDP and control group, as well as among the different HDP subgroups. (3) Results: The HDP group exhibited significantly reduced HRV parameters compared to healthy controls, indicating notable autonomic dysfunction. Speckle tracking echocardiography revealed lower GLS among women with HDP, particularly in those with SPE, compared to the control group. Diastolic dysfunction was also present in the HDP group. (4) Conclusions: HRV and GLS are valuable non-invasive tools for detecting autonomic dysfunction and cardiac performance impairments in pregnant women with hypertensive disorders. These findings suggest that autonomic and cardiac dysfunctions are prevalent in HDP.