LDL-Cholesterol-Lowering Effects of a Dietary Supplement Containing Onion and Garlic Extract Used in Healthy Volunteers

• Published in: Nutrients Vol. 16; no. 16; p. 2811
• Main Authors: Vezza, Teresa, Guillamón, Enrique, García-García, Jorge, Baños, Alberto, Mut-Salud, Nuria, García-López, Jose David, Gómez-Fernández, Germán O, Rodriguez-Nogales, Alba, Gálvez, Julio, Fonollá, Juristo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22-08-2024; MDPI
• Subjects: Adult; Anticholesteremic Agents; Antioxidants; Atherosclerosis; Biomarkers - blood; Blood Pressure - drug effects; Cellulose; Cholesterol; Cholesterol, LDL - blood; Diabetes; Dietary Supplements; Disease; Double-Blind Method; Female; Garlic; Garlic - chemistry; Healthy Volunteers; Humans; hypercholesterolemia; Hypercholesterolemia - blood; Hypercholesterolemia - drug therapy; Intervention; Lifestyles; Low density lipoprotein; low-density lipoprotein cholesterol; Male; Medical research; Middle Aged; Nitric oxide; Obesity; onion; Onions - chemistry; organosulfur compounds; Plant Extracts - pharmacology; Plasma; Triglycerides; United States > US; Spain; garlic; low-density lipoprotein cholesterol; onion; hypercholesterolemia; organosulfur compounds
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16162811

Hypercholesterolemia plays a pivotal role in the development and progression of cardiovascular diseases, and its prevention seems to be a crucial healthcare strategy to ameliorate these conditions. Subjects with mild hypercholesterolemia are frequently advised against using cholesterol-lowering drugs due to potential side effects, with an emphasis instead on prioritizing dietary adjustments and lifestyle modifications as the primary strategy. In this context, the use of dietary supplements based on medicinal plants may be recommended as a complementary approach to managing elevated cholesterol levels. The aim of this study was to investigate the safety and potential therapeutic effectiveness of a standardized formulation containing extracts from garlic and onions in addressing the health concerns of individuals with slightly elevated cholesterol levels. A controlled, randomized, double-blind, two parallel-group study was conducted over 8 weeks, with clinical visits scheduled at baseline, weeks 2 and 4, as well as at the end of the study. The results revealed significant reductions in both low-density lipoprotein cholesterol and total cholesterol levels among participants who received the extract. Additionally, improvements in blood pressure, as well as in oxidative and inflammatory markers were observed, thus suggesting its potential as a valuable therapeutic intervention for managing mild hypercholesterolemia.