Efficacy and Safety of Oral Administration of a Mixture of Probiotic Strains in Patients with Psoriasis: A Randomized Controlled Clinical Trial

• Published in: Acta dermato-venereologica Vol. 99; no. 12; pp. 1078 - 1084
• Main Authors: Navarro-López, Vicente, Martínez-Andrés, Asunción, Ramírez-Boscá, Ana, Ruzafa-Costas, Beatriz, Núñez-Delegido, Eva, Carrión-Gutiérrez, Miguel A, Prieto-Merino, David, Codoñer-Cortés, Francisco, Ramón-Vidal, Daniel, Genovés-Martínez, Salvador, Chenoll-Cuadros, Empar, Pérez-Orquín, José M, Picó-Monllor, José A, Chumillas-Lidón, Sara
• Format: Journal Article
• Language: English
• Published: Sweden Medical Journals Sweden 01-11-2019
• Subjects: Administration, Oral; Adolescent; Adult; Aged; dermatology; Double-Blind Method; Female; Gastrointestinal Microbiome; Humans; Male; microbiome; microbiota; Middle Aged; probiotic; Probiotics - administration & dosage; Probiotics - adverse effects; psoriasis; Psoriasis - diagnosis; Psoriasis - immunology; Psoriasis - microbiology; Psoriasis - therapy; Recurrence; Remission Induction; Spain; Time Factors; Treatment Outcome; Young Adult; Spain; microbiota; probiotic; dermatology; microbiome; psoriasis
• ISSN: 0001-5555; 1651-2057
• DOI: 10.2340/00015555-3305

The aim of this 12-week randomized, double-blind, placebo-controlled trial was to determine the efficacy and safety of a probiotic mixture in the reduction of psoriasis severity. Ninety 18-70-year-old adults with plaque psoriasis were randomized into probiotic and placebo groups. At 12-week follow-up, 66.7% of patients in the probiotic group and 41.9% in the placebo group showed a reduction in Psoriasis Area and Severity Index of up to 75% (p < 0.05). A clinically relevant difference was observed in Physician Global Assessment index: 48.9% in the probiotic group achieved a score of 0 or 1, compared with 30.2% in the placebo group. The results of follow-up 6 months after the end of the study showed a lower risk of relapse after the intake of the probiotic mixture. Analysis of gut microbiota confirmed the efficacy of the probiotic in modulation of the microbiota composition.