Comparative characteristics of carotid atherosclerosis in patients with hypertension concurrent with chronic coronary heart disease among the indigenous and non-indigenous population of the Yamal-Nenets Autonomic District

• Published in: Terapevtic̆eskii arhiv Vol. 86; no. 10; pp. 47 - 51
• Main Authors: Gapon, L I, Sereda, T V, Leont'eva, A V, Gyl'tiaeva, E P
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 01-01-2014
• Subjects: Adult; atherosclerosis; blood lipid composition; Carotid Artery Diseases - diagnosis; Carotid Artery Diseases - ethnology; Carotid Intima-Media Thickness - statistics & numerical data; Comorbidity; Coronary Disease - diagnosis; Coronary Disease - ethnology; coronary heart disease; duplex scanning; Female; Humans; hypertension; Hypertension - diagnosis; Hypertension - ethnology; Male; Middle Aged; Population Groups - ethnology; Siberia - ethnology; Young Adult; Siberia
• ISSN: 0040-3660; 2309-5342

To evaluate the degree of carotid artery (CA) atherosclerotic lesion and lipid metabolic disturbances in patients with hypertension and in those with hypertension concurrent with coronary heart disease (CHD) in the indigenous and non-indigenous population living in the Yamal-Nenets Autonomic District.
Two hundred men and women aged 21 to 55 years (mean age 48.2 ± 0.7 years), who resided in the Far North, were examined. The patients were divided into 4 gender-and age-matched groups of 50 persons in each: 1) natives; 2) newcomers with hypertension only; 3) natives with CHD and hypertension; 4) non-natives with the above conditions. To study CA involvement, all the patients underwent duplex scanning of the brachiocephalic arteries at the extracranial level and blood lipid analysis in an outpatient setting (Salekhard).
In all the patients, common CA intima-media thickness was significantly greater than the upper limit of the normal range defined in the Guidelines, this indicator proved to be highest in the groups of indigenous people (p<0.001). The latter with CHD and hypertension more commonly tended to have atherosclerotic lesion in the left CA (p=0.06) than the non-indigenous people whereas the number of stenosis in other CAs was similar. In the natives versus the newcomers with CHD and hypertension, the atherogenic blood lipid composition was due to the higher levels of total cholesterol and low-density lipoproteins. In the non- indigenous patients with CHD and hypertension, the atherogenicity of the blood lipid composition was characterized by the higher levels of triglycerides (p=0.04) and very low-density lipoproteins (p=0.02) with the lower concentrations of high-density lipoproteins as compared to those in the natives with CHD and hypertension.