Predictive value of inflammatory factors on the efficacy of adjuvant Dexamethasone in the treatment of refractory purulent meningitis among pediatric patients

• Published in: Journal of medical biochemistry Vol. 43; no. 4; pp. 406 - 412
• Main Authors: Zhong, XiaoMei, Niu, QingJun, Yuan, XunLing
• Format: Journal Article
• Language: English
• Published: Serbia Society of Medical Biochemists of Serbia, Belgrade 15-06-2024
• Subjects: dexamethasone; inflammation factors; Original Paper; pediatric refractory purulent meningitis; inflammation factors; Dexamethasone; pediatric refractory purulent meningitis
• ISSN: 1452-8258; 1452-8266
• DOI: 10.5937/jomb0-37618

The aim of this study was to figure out the predictive value of inflammatory factors on the efficacy of Dexamethasone adjuvant therapy for refractory purulent meningitis in children.
In, this study, a regression analysis method was employed to select a sample of 38 children with refractory purulent meningitis, 40 children with purulent meningitis, and 40 healthy children who visited to Ganzhou People's Hospital for physical These participants were then assigned to the Dexamethasone, standard care and the control groups. The inflammatory factors in the three groups were compared, and a multivariate Logisitic regression was analysis was conducted to examine the predictive indicators and efficacy of Dexamethasone treatment in children with refractory purulent meningitis.
The levels of CRP, TNF-a, IL-6, PCT and IL-1 were found to be significantly higher in the Dexamethasone group to both the standard care and the control (P < 0.05). Through multivariate Logisitic regression analysis, it was determined that CRP, TNF-a, IL-6, PCT, and IL-1 were reliable predictors of the efficacy of Dexamethasone treatment in children with refractory purulent meningitis. These biomarkers demonstrated good predictive performance, with CRP and IL-1 showing superior predictive performance.
Inflammatory factors have a certain predictive value for the efficacy of Dexamethasone adjuvant therapy for refractory purulent meningitis in pediatric patients.