Recent advances, challenges and updates on the development of therapeutics for malaria

• Published in: EXCLI journal Vol. 23; pp. 672 - 713
• Main Authors: Nandal, Rimmy, Kumar, Davinder, Aggarwal, Navidha, Kumar, Virender, Narasimhan, Balasubramanian, Marwaha, Rakesh Kumar, Sharma, Prabodh Chander, Kumar, Surender, Bansal, Nitin, Chopra, Hitesh, Deep, Aakash
• Format: Journal Article
• Language: English
• Published: Germany Leibniz Research Centre for Working Environment and Human Factors 01-01-2024; IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
• Subjects: antimalarials; artefenomel; cipargamin; clinical trials; malaria; Review; tafenoquine; antimalarials; tafenoquine; clinical trials; malaria; artefenomel; cipargamin
• ISSN: 1611-2156; 1611-2156
• DOI: 10.17179/excli2023-6856

Malaria has developed as a serious worldwide health issue as a result of the introduction of resistant
species strains. Because of the common chemo resistance to most of the existing drugs on the market, it poses a severe health problem and significant obstacles in drug research. Malaria treatment has evolved during the last two decades in response to
drug sensitivity and a return of the disease in tropical areas.
is now highly resistant to the majority of antimalarial drugs. The parasite resistance drew focus to developing novel antimalarials to combat parasite resistance. The requirement for many novel antimalarial drugs in the future year necessitates adopting various drug development methodologies. Different innovative strategies for discovering antimalarial drugs are now being examined here. This review is primarily concerned with the description of newly synthesized antimalarial compounds, i.e. Tafenoquine, Cipargamin, Ferroquine, Artefenomel, DSM265, MMV390048 designed to improve the activity of pure antimalarial enantiomers. In this review, we selected the representative malarial drugs in clinical trials, classified them with detailed targets according to their action, discussed the relationship within the human trials, and generated a summative discussion with prospective expectations.