Kikuchi-Fujimoto Disease: a Case Report

• Published in: Acta medica Iranica Vol. 53; no. 11; pp. 725 - 727
• Main Authors: Aznab, Mozaffar, Kamalian, Naser, Navabi, Jaffar, Kavianimoghadam, Kaveh
• Format: Journal Article
• Language: English
• Published: Iran Tehran University of Medical Sciences 01-11-2015
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Biopsy; Female; Histiocytic necrotizing lymphadenitis; Histiocytic Necrotizing Lymphadenitis - drug therapy; Histiocytic Necrotizing Lymphadenitis - physiopathology; Humans; Kikuchi-Fujimoto disease; Lymph Nodes; Prednisolone - therapeutic use; Kikuchi-Fujimoto disease; Histiocytic necrotizing lymphadenitis
• ISSN: 0044-6025; 1735-9694

Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is an idiopathic, self-limiting disorder and predominantly affects young women. We report a 35-year-old female who presented with soft to firm cervical lymphadenopathy and neck pain. She had multiple enlarged cervical nodes. Examination of other systems was normal. Lymph node biopsy was performed, and the histological features, and immunohistochemistry confirmed the diagnosis. The Patient was treated with non-steroidal anti-inflammatory drugs and low-dose prednisolone. A significant decrease in the size of lymph node and relief of neck pain occurred. During four years of follow-up, the patient developed no malignant disease or systemic and autoimmune diseases such as systemic lupus erythematosus. Kikuchi-Fujimoto disease is rare, clinicians should be aware of this condition as early diagnosis of the disease will lessen concerns of the patient's family.