Free radical processes in the pathogenesis of involutional skin changes

• Published in: Terapevtic̆eskii arhiv Vol. 84; no. 10; pp. 75 - 78
• Main Authors: Manturova, N E, Silina, E V, Stupin, V A, Smirnova, G O, Bolevich, S B
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 01-01-2012
• Subjects: Adolescent; Adult; Age Factors; Aged; aging; Colorimetry; cytoflavin; Drug Combinations; energy correction; Face - pathology; Face - physiopathology; Female; Flavin Mononucleotide - therapeutic use; free radical processes; Free Radicals - blood; Humans; Inosine Diphosphate - therapeutic use; involutional processes; Laser-Doppler Flowmetry; Lipid Peroxides - blood; Middle Aged; Neck - pathology; Neck - physiopathology; Niacinamide - therapeutic use; Oxygen - blood; Severity of Illness Index; skin; Skin Diseases - diagnosis; Skin Diseases - drug therapy; Skin Diseases - etiology; Succinates - therapeutic use; Treatment Outcome; Vitamin B Complex - therapeutic use; Young Adult
• ISSN: 0040-3660; 2309-5342

To study the role of free radical processes (FRP) in the development of involutional skin changes and their correction.
One hundred and twenty patients aged 18 to 74 years with various degrees of involutional facial and cervical skin changes were examined. Clinical and laboratory assessments were made over time. The oxygen and lipid peroxidase parameters of FRP were estimated; objective and subjective visualization, Doppler flowmetry of the facial skin, and colorimetric study of the skin color spectrum were done.
The imbalance between oxygen and lipid peroxide components of FRP was found to increase with advancing age. These processes correlate with the severity of involutional skin changes and objectify the early use of energy-correcting therapy (ECT). The incorporation of ECT with cytoflavin positively affects FRP values and clinical and instrumental findings of involutional facial and cervical skin changes, by improving microcirculation. The patients with first-second degree involutional skin changes achieved the best results.
The findings permit cytoflavin to be recommended as one of the components of therapy aimed to stabilize intradermal exchange processes as part cosmetic manipulations in aesthetic medicine.