Is Uric Acid a Marker in Obstructive Sleep Apnea Syndrome?

• Published in: Journal of Turkish Sleep Medicine Vol. 3; no. 3; pp. 73 - 78
• Main Authors: Elif Torun Parmaksız, Salepçi, Banu, Güngör, Gülten Aktın, Cömert, Sevda, Ergün Parmaksız
• Format: Journal Article
• Language: English; Turkish
• Published: Itanbul Galenos Publishing House 01-09-2016; Galenos Yayinevi
• Subjects: apnea hypopnea index; Chronic obstructive pulmonary disease; Diabetes; Insomnia; Metabolism; Mortality; Obstructive sleep apnea syndrome; Sleep; Sleep apnea; Uric acid
• ISSN: 2148-1504; 2148-1504
• DOI: 10.4274/jtsm.228

Objective: Uric acid which arises in conditions such as cardiovascular diseases, Chronic kidney failure, metabolic syndrome is a strong and independent marker of morbidity and mortality. Hypoxia-arousal-reoxygenation cycles that observed in Obstructive sleep apnea syndrome (OSAS) throughout the night increase adenosine triphosphate degradation and cause uric acid production, an end-product of purine metabolism. We aimed to evaluate the relationship between OSAS and serum uric acid levels. Materials and Methods: Subjects who were evaluated by polysomnography (PSG) in our sleep laboratory were prospectively analysed. Demographic data, detailed history including comorbidities, smoking history of all the patients were recorded. PSG was performed all night and complete blood count and biochemical analysis were done. Results: Total of 449 subjects with a mean age of 47.78 (18-65) were included in the study. The study population consisted of 283 (63%) male and 166 (37%) female. According to PSG data, 43 subjects had apnea-hypopnea index was <5 and 406 subjects had OSAS. As comorbidities evaluated, hypertension in 135 (30%), diabetes mellitus in 80 (18%), coronary heart disease in 53 (12%), asthma in 53 (12%), dyslipidemia in 14 (3%), chronic obstructive pulmonary disease in 12 (2.7%) patients were found. Serum uric acid level was high in 75 cases; 3 of which was in control group and 72 of which was in OSAS group. Uric acid level was increased in 13 patients with mild OSAS, 25 patients with moderate OSAS and 34 patients with severe OSAS. Serum uric acid level was significantly higher in OSAS group compared to control group. Conclusion: Complete blood count data and serum urea levels were found similar in both groups, whereas creatinine was significantly higher in OSAS patients. Serum uric acid and creatinine levels were increasing significantly as the disease got more severe. When patient uric acid levels were compared by gender, mean uric acid level was 5.29 mg/dL in women and 6.58 mg/dL in men; the difference between genders was statistically significant.