ELABORATION OF METHOD FOR GRADIENT AND ACTIVE CALCIUM RENAL REABSORBTION DEFINITION FOR FUNCTIONAL ESTIMATION OF TRANSPLANTED KIDNEY

• Published in: Vestnik transplantologii i iskusstvennykh organov Vol. 12; no. 1; pp. 51 - 55
• Main Authors: I. P. Yermakova, V. P. Buzulina, I. E. Borodulin, I. A. Pronchenko, N. A. Tomilina
• Format: Journal Article
• Language: Russian
• Published: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 01-06-2010
• Subjects: calcium; chanel calcium reabsorbtion; kidney transplantation
• ISSN: 1995-1191
• DOI: 10.15825/1995-1191-2010-1-51-55

The dependence between minute calcium and sodium excretion from 1 L glomerular filtrate (CaE/GFR; NaE/GFR) with NaE/GFR from 0,1 to 9,71 mmol/l GFR was studied in 103 health volunteers. There was received asymptotique curve with r2 = 0,54; Y = 0,06 [1 – exp (–x/2,34)]. The nomogramm with confidence intervals of 95% was built. On the basis of renal physiology it was offered differentiate gradual (to electrochemical gradiate created by sodium reabsorbtion) and active calcium reabsorbtion. It was assumed that gradual calcium reabsorbtion is equel to sodium reabsorbtion and may be estimate by NaE/GFR, CNa/GFR. We considered that active calcium reabsorbtion is normal if the correlation between CaE/GFR and NaE/GFR is inside being decreased if the correlation is higher and increased if the correlation is lower probable intervals. We proposed T-score CaE/GFR as the quantative parameter of active calcium reabsorbtion. It varied in health volunteers from –1,74 to +2,15. The method was applied in 236 recipients of allotransplanted kidney.