Human YRNA 4 (HY4) plasma levels are a prognostic indicator of SARS-CoV-2 infection clinical severity

SARS-CoV-2 infection can result in a range of outcomes from asymptomatic/mild disease to severe COVID-19/fatality. In this study, we investigated the differential expression of small noncoding RNAs (sncRNAs) between patient cohorts defined by disease severity. We collected plasma samples, stratified...

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Bibliographic Details
Published in:	microPublication biology Vol. 2023
Main Authors:	Olliff, Nathaniel S, Hunt, Miles A, Paudel, Sunita S, Nguyen, Kevin N, Delcher, Haley A, DeMeis, Jeffrey D, Roberts, Justin T, Fouty, Brian W, Audia, Jonathon P, Kim, Jin H, Borchert, Glen M
Format:	Journal Article
Language:	English
Published:	Caltech Library 01-01-2023
Subjects:	Expression Data Human New Finding
Online Access:	Get full text
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Summary:	SARS-CoV-2 infection can result in a range of outcomes from asymptomatic/mild disease to severe COVID-19/fatality. In this study, we investigated the differential expression of small noncoding RNAs (sncRNAs) between patient cohorts defined by disease severity. We collected plasma samples, stratified these based on clinical outcomes, and sequenced their circulating sncRNAs. Excitingly, we found YRNA HY4 displays significant differential expression (p=0.025) between patients experiencing mild and severe disease. In agreement with recent reports identifying plasma YRNAs as indicators of influenza infection severity, our results strongly suggest that circulating HY4 levels represent a powerful prognostic indicator of likely SARS-CoV-2 patient infection outcome.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The authors declare that there are no conflicts of interest present.
ISSN:	2578-9430
DOI:	10.17912/micropub.biology.000925