Mechanism of action of isothiocyanates. A review

Isothiocyanates (ITC), originating from the enzymatic degra- dation of glucosinolates (GSL), which are secondary metabolites of Brassicaceae plants, exhibit anticarcinogenic properties due to their ability to induce cytoprotective genes. The mechanisms of cytotoxic and cytostatic effects of ITC incl...

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Bibliographic Details
Published in:	Agronomía colombiana Vol. 31; no. 1; pp. 68 - 75
Main Author:	Molina VARGAS, lUIS Federico
Format:	Journal Article
Language:	English Portuguese Spanish
Published:	Bogota Universidad Nacional de Colombia 01-04-2013 Universidad Nacional de Colombia, Facultad de Agronomía Centro Editorial of Facultad de Ciencias Agrarias, Universidad Nacional de Colombia
Subjects:	AGRONOMY apoptosis estrés oxidativo fitoalexinas glucosinolatos metabolitos secundarios fitoalexinas secondary metabolites glucosinolates apoptosis estrés oxidativo glucosinolatos metabolitos secundarios oxidative stress phytoalexins
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Summary:	Isothiocyanates (ITC), originating from the enzymatic degra- dation of glucosinolates (GSL), which are secondary metabolites of Brassicaceae plants, exhibit anticarcinogenic properties due to their ability to induce cytoprotective genes. The mechanisms of cytotoxic and cytostatic effects of ITC include induction of apoptosis, inhibition of cell cycle progression and inhibition of angiogenesis. Regulation of apoptosis by ITC is accomplished primarily through the mitochondrial release of cytochrome c, Bcl-2 family regulation, MAPK signaling and subsequent activation of caspases. A significant portion of the chemopreventive effects of ITC may be associated with the inhibition of the metabolic activation of carcinogens by cytochrome P450 (phase I), along with increased induction of phase II detoxifying enzymes.
ISSN:	0120-9965 2357-3732