Delayed allergic reaction to amlodipine with a positive lymphocyte transformation test

• Published in: Revista alergia Mexico (Tecamachalco, Pueblo, Mexico : 1993) Vol. 64; no. 4; pp. 505 - 508
• Main Authors: Monge-Ortega, Olga Patricia, Domínguez-Ortega, Javier, González-Muñoz, Miguel, Cabañas, Rosario, Lluch-Bernal, Magdalena, Fiandor, Ana, Bravo-Gallego, Luz Yadira, Quirce, Santiago
• Format: Journal Article
• Language: English; Spanish
• Published: Mexico Colegio Mexicano de Inmunología Clínica y Alergia, A.C 01-10-2017
• Subjects: Alergia; Amlodipino; Prueba de transformación linfocitaria; Reacción tardía; Amlodipine; Lymphocyte transformation test; Delayed reaction
• ISSN: 0002-5151; 2448-9190
• DOI: 10.29262/ram.v64i4.312

Amlodipine is one of the third generation dihydropyridine calcium channel blockers used for hypertension. Mild, moderate and severe reactions have been reported with calcium channel blockers. Cross-reactivity among these drugs has not been established.
We have presented the case of a patient who developed a delayed pruritic, and erythematous maculopapular skin exanthema after the intake of amlodipine. A positive lymphocyte transformation test (LTT) confirmed the implication of amlodipine in the reaction and showed positivity to another calcium channel blocker, nifedipine, demonstrating cross reactivity.
This is the first reported case of hypersensitivity to amlodipine in which the involvement of the drug is confirmed by a positive TTL. TTL could become a good diagnostic alternative for patients who experience late reactions to amlodipine and possibly cross-reactivity with nifedipine.