Synthesis of Bi 2 WO 6-x nanodots with oxygen vacancies as an all-in-one nanoagent for simultaneous CT/IR imaging and photothermal/photodynamic therapy of tumors

• Published in: Nanoscale Vol. 11; no. 32; p. 15326
• Main Authors: Wang, Shun, Wang, Han, Song, Cen, Li, Zhicong, Wang, Zhaojie, Xu, Hao, Yu, Wanjian, Peng, Chen, Li, Maoquan, Chen, Zhigang
• Format: Journal Article
• Language: English
• Published: England 15-08-2019
• Subjects: Animals; Bismuth - chemistry; Cell Line, Tumor; Cell Survival - drug effects; Cell Survival - radiation effects; Infrared Rays; Iohexol - analogs & derivatives; Iohexol - chemistry; Iohexol - pharmacology; Mice; Nanostructures - chemistry; Nanostructures - therapeutic use; Nanostructures - toxicity; Neoplasms - diagnosis; Neoplasms - pathology; Neoplasms - therapy; Oxygen - chemistry; Photochemotherapy; Phototherapy; Singlet Oxygen - chemistry; Singlet Oxygen - metabolism; Temperature; Tissue Distribution; Tomography, X-Ray Computed; Tungsten Compounds - chemistry
• ISSN: 2040-3372
• DOI: 10.1039/C9NR05236D

All-in-one nanoagents with a single-component and all-required functions have attracted increasing attention for the imaging-guided therapy of tumors, but the design and preparation of such nanoagents remain a challenge. Herein, we report the introduction of oxygen vacancies to traditional semiconductors with heavy-metal elements for tuning photoabsorption in the near infrared (NIR) region, by using Bi2WO6 (band-gap: ∼2.7 eV) as a model. Bi2WO6-x nanodots with sizes of ∼3 or ∼8 nm have been prepared by a facile coprecipitation-solvothermal method assisted by citric acid (CA, 0.1-1.5 g) as the reduction agent. CA confers the removal of O atoms from the [Bi2O2]2+ layer during the solvothermal process, resulting in the formation of plenty of oxygen vacancies in the Bi2WO6-x crystal. As a result, NIR photoabsorption of Bi2WO6-x nanodots can be remarkably enhanced with the increase of the CA amount from 0 to 1.0 g. Under irradiation of a single-wavelength (808 nm, 1.0 W cm-2) NIR laser, black Bi2WO6-x-CA1.0 nanodots can not only efficiently produce a sufficient amount of heat with a photothermal conversion efficiency of 45.1% for photothermal therapy, but also generate singlet oxygen (1O2) for photodynamic therapy. Furthermore, due to the presence of heavy-metal (Bi and W) elements, Bi2WO6-x-CA1.0 nanodots have high X-ray attenuation ability for CT imaging. After the Bi2WO6-x-CA1.0 nanodot dispersion is injected into the tumor-bearing mice, the tumor can be imaged by using CT and an IR thermal camera. After irradiation with a single-wavelength (808 nm, 1.0 W cm-2, 10 min) NIR laser, the tumor can be completely suppressed by the synergic photothermal and photodynamic effects of Bi2WO6-x-CA1.0 nanodots, without recurrence and treatment-induced toxicity. Therefore, Bi2WO6-x nanodots have great potential as a novel all-in-one nanoagent for the imaging and phototherapy of tumors.