Methodological approaches to the morphological study of placenta, extraplacental membranes and umbilical cord in infectious pathology

• Published in: Arkhiv patologii Vol. 86; no. 5; p. 53
• Main Author: Kolobov, A V
• Format: Journal Article
• Language: English; Russian
• Published: Russia (Federation) 2024
• Subjects: COVID-19 - pathology; Extraembryonic Membranes - microbiology; Extraembryonic Membranes - pathology; Female; Humans; Infant, Newborn; Placenta - pathology; Placenta - virology; Placenta Diseases - pathology; Placenta Diseases - virology; Pregnancy; Pregnancy Complications, Infectious - pathology; Pregnancy Complications, Infectious - virology; SARS-CoV-2; Umbilical Cord - pathology; placentitis; placenta; viruses; ascending intraamniotic infection
• ISSN: 0004-1955
• DOI: 10.17116/patol20248605153

The functional state of the placenta and extraplacental membranes, determined by their morphological characteristics, is of key importance in the implementation of both physiological and complicated pregnancy. Of great practical value for the diagnosis of congenital infections is the morphological study of the placenta, extraplacental membranes and umbilical cord, which allows optimizing the supervision of newborns and preventing the development of severe perinatal complications. This article presents methodological approaches to the morphological study of the placenta, extraplacental membranes and umbilical cord in infectious pathologies of both bacterial (ascending intraamniotic infection) etiology and viral placentitis caused by parvovirus, human immunodeficiency virus, respiratory syncytial virus, viruses of the Herpesviridae family - herpes simplex viruses types 1 and 2, cytomegalovirus and Epstein - Barr virus) and SARS-CoV-2 with a description of the morphological features of typical changes and immunohistochemical verification of their etiology.