Clinical and morphological characteristics of lung sequestration

• Published in: Arkhiv patologii Vol. 86; no. 5; p. 15
• Main Authors: Kuznetsova, I A, Rybakova, M G, Dvorakovskaya, I V, Tikhonova, Yu A, Markusevich, E V, Danilova, D M
• Format: Journal Article
• Language: English; Russian
• Published: Russia (Federation) 2024
• Subjects: Adult; Bronchopulmonary Sequestration - pathology; Cystic Adenomatoid Malformation of Lung, Congenital - pathology; DNA-Binding Proteins; Female; Humans; Keratin-5 - metabolism; Keratin-6 - metabolism; Lung - pathology; Male; Middle Aged; Transcription Factors; lung sequestration; pathological anatomy; congenital malformations
• ISSN: 0004-1955
• DOI: 10.17116/patol20248605115

To study the clinical and morphological manifestations of lung sequestration.
Surgical material (lung tissue) of 18 patients (2017-2021) and 8 archival observations (1972-1994) of confirmed lung sequestration were examined. Histological staining (hematoxylin and eosin, Schiff reagent, Ziehl-Neelsen, picrofuchsin according to Van Gieson) and immunohistochemical reactions with antibodies to SMA, TTF1, CK5/6 (DAKO) were performed.
The ratio of men to women was 5:4; the average age of the patients was 35 years. Lung sequestration is localized mainly in the lower lobe segments, the left lung is involved in the pathological process more often. The cystic variant of lung sequestration with a chronic inflammatory process prevailed. Histological examination revealed the similarity of lung sequestration with congenital adenomatous lung malformation type 2 and rhabdomyomatous dysplasia. The respiratory and bronchial epithelium lost differentiation in the sequestered area.
The morphological picture of lung sequestration is nonspecific and can manifest itself in various types of inflammatory reactions and remodeling of lung tissue.