OC54 OUTCOME OF A CONTINOUS FLOW PUMP (JARVIK 2000) AS BRIDGE TO TRANSPLANTATION OR DESTINATION THERAPY IN PEDIATRIC PATIENTS: SINGLE CENTER EXPERIENCE

• Published in: Journal of cardiovascular medicine (Hagerstown, Md.) Vol. 19 Suppl 2: Abstracts of the XIX Meeting of the Società Italiana di Chirurgia Cardiaca, Rome, November 23rd - 25th, 2018; no. Supplement 2; p. e9
• Main Authors: Perri, G, Filippelli, S, Di Molfetta, A, Testa, G, Iodice, F, Adorisio, R, Iacobelli, R, Massetti, M, Amodeo, A
• Format: Journal Article
• Language: English
• Published: Italian Federation of Cardiology. All rights reserved 01-11-2018
• ISSN: 1558-2027; 1558-2035
• DOI: 10.2459/01.JCM.0000549871.57072.9e

BACKGROUND:Use of intra-corporeal ventricular assist devices (VAD) in children has become increasingly popular over the years. We describe our experience with “Jarvik 2000” LVAD both as destination therapy (DT) and as bridge to transplantation (BTT) in pediatric patients.
METHODS:We reviewed 14 consecutive children assisted with “Jarvik 2000” LVAD for end stage heart failure from October 2010 to May 2018. Primary diagnosis was dilated cardiomyopathies (DCM) in Duchenne Muscular Dystrophy (DMD) in 7 patients and primary DCM in 7. Data collected include, age and weight at implantation, indication to support, post-operative complications and outcome.
RESULTS:“Jarvik 2000” was implanted in 13 patients, while “Infant Jarvik” was used in 1. Mean age and weight at time of implantation were 15.5 years (0.9 - 17.4 yrs) and 45 kilograms (5 – 88 kg) respectively. Six patients with DMD DCM and one patient, with primary DCM and severe preexisting neurological, received LVAD as DT while in 7 children, all with primary DCM, the device have been used as BTT. In this group, at mean follow-up time of 27.4 ± 17 months, 4 death occurred, 2 for VAD- related cerebral bleeding. All BTT patients underwent successful transplantation and survived to hospital discharge while 1 child died after 1 months from OHtx due to lung infection.
CONCLUSIONS:Jarvik 2000 LVAD can be successfully implanted in children as BTT or as DT. Thanks to versatility and reliability even in extreme condition, this device may be considered an alternative therapeutic option for pediatric end-stage heart failure.