ASSOCIATION OF IMMUNOHISTOCHEMICAL EXPRESSION OF 8OHDG WITH THE PATHOGENESIS ACTINIC CHEILITIS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 134; no. 3; p. e185
• Main Authors: Medeiros, Cristianne Kalinne Santos, De Oliveira Varela, Cíntia Barreto, De França, Glória Maria, Da Cruz Lima, Jabes Gennedyr, Serrão, Maria Do Carmo Pessoa Nogueira, Da Silveira, Éricka Janine, De Oliveira, Patrícia Teixeira
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2022
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2022.01.554

The aim of this study was to investigate the immunohistochemical expression of 8-OHdG in 57 cases of actinic cheilitis (AC) and its association with clinicopathologic parameters.
The expression of 8-OHdG was evaluated semiquantitatively and the data were analyzed using the nonparametric Mann-Whitney and Kruskal-Wallis tests to identify statistically significant differences in the expression of 8-OHdG according to the World Health Organization histopathologic grading of oral epithelial dysplasia in the AC samples analyzed.
Most cases exhibited strong immunoreactivity to the anti-8-OHdG antibody (64.9%). No significant differences were observed in the expression of 8-OHdG according to the clinical characteristics of AC or between the different degrees of epithelial dysplasia (P = .35).
The strong immunoexpression of 8-OHdG regardless of the morphologic severity of AC demonstrates the participation of oxidative DNA damage in the pathogenesis of this condition.