ASSOCIATION BETWEEN GREM1 AND NONSYNDROMIC CLEFT LIP WITH OR WITHOUT CLEFT PALATE IN THE BRAZILIAN POPULATION

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e270
• Main Authors: VIENA, CAMILA SANE, MACHADO, RENATO ASSIS, VEIGA, PATRICIA DE CASTRO, MEDRADO, ALENA PEIXOTO, COLETTA, RICARDO DELLA, REIS, SILVIA REGINA DE ALMEIDA
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.733

Background: GREM1, which encodes Gremlin 1, an antagonist of bone morphogenic proteins with effect proliferation and apoptosis. GREM1 has been considered a candidate gene for nonsyndromic cleft lip with or without cleft palate (NSCL±P). Objective: Investigate associations of single nucleotide polymorphisms (SNPs) in GREM1 and NSCL±P risk in the Brazilian population. Study Design: This study was based on the combination of 2 complementary approaches: case-parent trios and case-control analysis. Applying TaqMan allelic discrimination assays, we evaluated the variants rs16969681, rs16969816, rs16969862, and rs1258763 in 325 case-parent trios and in 1588 isolated samples in a case-control study. Results: The risk alleles of all SNP were undertransmitted in NSCL±P trios, though the case-control analysis confirmed only the association with rs16969862 alleles (OR, 0.78; 95% CI, 0.63-0.96; P = .02). Conclusion: The GREM1 is involved in the etiology of NSCL±P in the Brazilian population. Funding Disclosure: National Foundation for the Development of Higher Education (FUNADESP) and Research Foundation of the State of Bahia (FAPESB), Brazil.