AGGRESSIVE DIFFUSE LARGE B-CELL LYMPHOMA OF THE TONGUE BASE: A CASE REPORT

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 136; no. 1; p. e26
• Main Authors: MENDES, Tássia Caroline da Costa, de SOUZA, Ana Paula Ferreira, PENAFORT, Paulo Victor Mendes, BARREIROS, André Luiz Carvalho, DUTRA, Israel Fontes, VARGAS, Pablo Augustin, CÂMARA, Jeconias
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-07-2023
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2023.03.042

The diffuse large B-cell lymphoma (DLBCL) is the most frequently reported subtype of Non-Hodgkin Lymphoma of the mouth. A 44-year-old male patient, smoker, alcoholic, presented a lesion on the tongue base (right), with four months of evolution, painful symptoms, and limited mouth opening. An incisional biopsy was performed, followed by a histopathological examination that showed proliferation of juxtaposed cells with ample eosinophilic cytoplasm and large nucleus with dispersed chromatin or sometimes hyperchromatic. In addition, numerous mitoses and areas of apoptotic bodies were observed. An immunohistochemical exam showed positivity for LCA, CD20, and Ki67 with proliferation index >90% and negativity for CD3, CD10, CD138, Bcl-2, AE1/AE3, S100, and Desmin. Thus, the diagnosis of DLBCL was established but the patient died before starting cancer treatment.