ORAL LICHEN PLANUS OR ORAL LICHENOID LESION IN ASSOCIATION WITH CHEMOTHERAPY TREATMENT FOR NON-HODGKIN LYMPHOMA?

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 134; no. 3; p. e96
• Main Authors: Marques, Letícia Côgo, De Almeida Lima Borba Lopes, Amanda, De Pinho Montovani, Pâmella, De Medeiros Nunes Da Silva, Laíza Angela, Conde, Danielle Castex, Silva, Arley, Cunha, Karin Soares
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2022
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2022.01.091

The diagnosis of oral lichenoid lesions (OLLs) is a challenge because they can be clinically and histologically indistinguishable from oral lichen planus (OLP), but the former is associated with a triggering factor. Several medications can be involved in the pathogenesis of OLLs, such as anti-inflammatory, anticonvulsant, antihypertensive, antiretroviral, and chemotherapeutic medications and antibiotics. This work report 2 cases of OLLs in patients with non-Hodgkin lymphoma types B and T after chemotherapy and adjuvant medications. In both cases, oral lesions presented reticular, atrophic, erosive/ulcerated, and plaque patterns. The diagnosis of OLL was initially established in both cases by the association of histopathology and history of onset of lesions after the use of medications. However, during more than 2 years of follow-up, although the patients have presented a significant improvement in the oral clinical picture, they still have some lesions, which makes the differential diagnosis between OLP and OLL even more challenging.