STROMAL EXPRESSION OF TWIST AND PODOPLANIN IN ORAL TONGUE AND LOWER LIP SQUAMOUS CELL CARCINOMAS

• Published in: Oral surgery, oral medicine, oral pathology and oral radiology Vol. 130; no. 3; p. e259
• Main Authors: ROLIM, LARISSA SANTOS AMARAL, MAFRA, RODRIGO PORPINO, COSTA, CARLA SAMILY DE OLIVEIRA, SANTOS, HELLEN BANDEIRA DE PONTES, SOUZA, LéLIA BATISTA DE, PINTO, LEãO PEREIRA
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2020
• ISSN: 2212-4403; 2212-4411
• DOI: 10.1016/j.oooo.2020.04.690

Objective: To analyze podoplanin (PDPN) and Twist stromal immunoexpression profiles in a series of oral tongue squamous cell carcinoma (OTSCC) and lower lip squamous cell carcinoma (LLSCC) cases and evaluate their relationship with clinical-pathologic parameters. Study Design: PDPN and Twist immunoexpression were qualitatively evaluated by analyzing stromal fibroblast staining. The statistical associations and correlations with clinicopathologic characteristics were verified by the Mann-Whitney and Spearman tests. Results: In LLSCC, the male-to-female ratio was 3:1 with a mean age ± standard deviation (SD) of 66.8 ± 15.1 years, with the seventh decade being the most affected age group. In OTSCC, the male-to-female ratio was 3:1, with a mean age ± SD of 61.0 ± 12.7 years, with the sixth decade being the most affected age group. Regarding the clinical parameters in both lesions, there were no statistically significant results for PDPN; for Twist, stromal immunoexpression was statistically significant for cases in the earliest stages (I and II). In the Spearman test, a significant positive correlation was observed only in LLSCC cases (P< .05). Conclusion: It can be inferred that there is a relationship between the concomitant expression of Twist and PDPN in the stroma and that the Twist expression in the early stages is involved in the onset of carcinogenesis in OTSCC cases.