The use of Botulinum toxin in various urological conditions

• Published in: Wiadomości lekarskie (1960) Vol. 77; no. 2; p. 348
• Main Authors: Kondratskyi, Vitalii, Nawrot, Piotr, Szepelska, Ada, Boblewska, Justyna, Sowińska, Izabela, Sygnowski, Michał, Jędrys, Wiktoria, Bienia, Grzegorz, Kosowski, Tomasz
• Format: Journal Article
• Language: English
• Published: Poland 2024
• Subjects: Botulinum Toxins, Type A - therapeutic use; Humans; Neuromuscular Agents - therapeutic use; Urinary Bladder, Overactive - drug therapy; chronic pelvic pain; bladder pain syndrome; Botulinum toxin; overactive bladder; detrusor overactivity
• ISSN: 0043-5147
• DOI: 10.36740/WLek202402124

Aim: The objective of this review paper is to comprehensively analyze and summarize the current understanding and clinical applications of Botulinum toxin in the field of urology.
Materials and Methods: The materials and methods for this review paper involved an extensive literature search on the use of Botulinum toxin in urology. Multiple online databases such as PubMed, Web of Science, and Google Scholar were utilized to gather peer-reviewed articles, clinical trials, and relevant books published within the last decades. A few articles used in the review come from before 21 century because the information is essential to fully describe the topic. Studies were selected based on their relevance to the topic, with a focus on those that reported on the clinical applications of Botulinum toxin in urology - we use information from other review papers, clinical trials and research papers. To expand the database, we have looked through the literature not only in English but also other languages. Thanks to this method we were able to compare the results from different countries and scientific groups all over the world. Data extracted from these sources were then analyzed and synthesized to provide a comprehensive overview of the subject matter.
Conclusions: In conclusion, Botulinum toxin has shown significant promise and utility in the field of urology. Its ability to effectively relax muscles has led to its application in a variety of urological conditions, including NDO, OAB, BPS/IC, DSD, BPH, CPP, and PE. The effectiveness and safety of Botulinum toxin have been demonstrated in numerous studies, providing a robust evidence base for its clinical use. However, further research is needed to optimize the administration methods, dosage, and treatment protocols. Additionally, more randomized controlled trials are required to establish the long-term safety and efficacy of Botulinum toxin, especially for conditions for which the current data is limited. Overall, Botulinum toxin represents a valuable tool in the urologist's armamentarium and is likely to continue to be an area of active research and development in the future.