Chemical constituents from Cyathostemma wrayi king and their chemophenetic significance

• Published in: Biochemical systematics and ecology Vol. 117; p. 104916
• Main Authors: Sulaiman, Syazreen Nadia, Othman, Muhamad Aqmal, Md Din, Mohd Fadzli, Awang, Khalijah, Zahari, Azeana, Liew, Sook Yee
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01-12-2024
• Subjects: Alkaloids; Annonaceae; Aporphines; Cyathostemma wrayi; Alkaloids; Annonaceae; Cyathostemma wrayi; Aporphines
• ISSN: 0305-1978
• DOI: 10.1016/j.bse.2024.104916

The phytochemical studies on the bark of Cyathostemma wrayi King resulted in the identification of ten alkaloids consisting of four oxoaporphines; lysicamine (1), atherospermidine (2), thalicminine (3), liriodenine (4), five aporphines; xylopine (5), nornuciferine (6), annonaine (7), norstephalagine (8), asimilobine (9), and one propaporphine; stepharine (10). The structural characterisation of all the isolated alkaloids was confirmed through the analysis of spectroscopic data and comparison with literature data. This is the first report on the alkaloids of Cyathostemma wrayi and also the first report on the occurrence of aporphine (1–3) and proaporphine (5–10) alkaloids in the genus of Cyathostemma. In addition, the chemophenetic significance of the isolated alkaloids was summarized.
•Phytochemical investigation of Cyathostemma wrayi were reported for the first time.•Nine out of ten alkaloids were first isolated from the genus of Cyathostemma.•The chemophenetic significance of the isolated alkaloids was summarized.