Abstract 14447: Multi-Center Evaluation of Stress Myocardial Blood Flow by Cardiac Magnetic Resonance in Known and Suspected Ischemic Heart Disease: Preliminary Findings From the AQUA-MBF Initiative

• Published in: Circulation (New York, N.Y.) Vol. 146; no. Suppl_1; p. A14447
• Main Authors: Wang, Shuo, Wang, Haonan, Benovoy, Mitchel, Ng, Ming-Yen, Kim, Paul, Singh, Amita, Patel, Hena, Saeed, Ibrahim, Pontone, Gianluca, Mushtaq, Saima, Urmeneta, Javier, Hillier, Elizabeth, Gormsen, Lars C, Laustsen, Christoffer, Janich, Martin A, Salerno, Michael, Hirsch, Alexander, Lubberink, Mark, Maceira, Alicia, Monmeneu, Jose, Pazhenkottil, Aju P, Nagpal, Prashant, Friedrich, Silke, Gutbrod, Joseph, Flournoy, Caroline, Tada, Yuko, Tsun Hei, Sin, Fong, Ambrose Ho Tung, Cheng, Ka Man Carmen, Goh, Victor K, Madsen, Simon, Arai, Andrew E, Friedrich, Matthias G, Patel, Amit R
• Format: Journal Article
• Language: English
• Published: Lippincott Williams & Wilkins 08-11-2022
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.146.suppl_1.14447

IntroductionQuantitative myocardial blood flow (MBF) analysis using stress cardiac magnetic resonance (CMR) has been shown to detect obstructive coronary artery disease (CAD) and coronary microvascular dysfunction (CMD) in several mostly small, single-center studies. The AQUA-MBF (A ssessment of QUA ntitative MBF) study is a multicenter initiative involving 16 centers. HypothesisThe goal of this sub-study is to determine if MBF can differentiate CAD, CMD, and normal volunteers in this multicenter setting. MethodsWe present data from 53 subjects (15 with CAD, 20 at risk for CMD and 18 controls) who underwent vasodilator stress CMR (Figure) using 1.5T and 3.0T MR scanners (General Electric). At risk for CMD was defined as having diabetes and 2 other risk factors in absence of ≥50% stenosis based on coronary CT. CAD was defined as the presence of stenosis ≥70% based on invasive coronary angiography. Stress perfusion images were acquired using the dual sequence technique. Stress MBF was measured in each of the 16 AHA segments using Fermi deconvolution (Circle Cvi42). In the CAD group, each segment was further classified as having late gadolinium enhancement (LGE), supplied by CAD, or a normal remote territory. The means of the 5 groups were compared using one-way analysis of variance. ResultsThe segmental stress MBF (ml/g/min) for the 5 groups are shown in figure. Compared to the normal group, segmental stress MBF in 4 disease groups were significantly lower (p<0.001). Segmental MBF in those at risk for CMD was lower than normal segments and greater than CAD segments (p<0.001). LGE and CAD segments had the lowest stress MBF but similar to each other (p=0.9). ConclusionsIn this multicenter study, we show that quantification of MBF using the dual sequence stress perfusion CMR technique can differentiate diseased from healthy myocardium and also between obstructive CAD and those at risk for CMD.