Synthesis and medical applications of oligosaccharides

Our understanding of the different glycoconjugates present on cells, proteins and entire organisms is lagging far behind advances in genomics and proteomics. Carbohydrate sequencing and the synthesis of defined oligosaccharides are two key technologies that have contributed to progress in glycomics...

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Bibliographic Details
Published in:	Nature Vol. 446; no. 7139; pp. 1046 - 1051
Main Authors:	Werz, Daniel B, Seeberger, Peter H
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 26-04-2007
Subjects:	Animals Biological research Biomedical research Biosynthesis Carbohydrates Cellular biology Chemical synthesis Genomics Glycomics Humans Medical research Medicine, Experimental Methods Oligosaccharides Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - immunology Oligosaccharides - therapeutic use Proteomics Vaccines Vaccines - chemistry Vaccines - immunology Switzerland
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Summary:	Our understanding of the different glycoconjugates present on cells, proteins and entire organisms is lagging far behind advances in genomics and proteomics. Carbohydrate sequencing and the synthesis of defined oligosaccharides are two key technologies that have contributed to progress in glycomics research. Synthetic tools and high-throughput experiments such as carbohydrate arrays are beginning to affect biological research. These techniques are now being applied to the development of carbohydrate-based diagnostics, vaccines and therapeutics.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0028-0836 1476-4687 1476-4679
DOI:	10.1038/nature05819