Hitting hotspots: spatial targeting of malaria for control and elimination

In more academic terms, an active focus of malaria transmission is a geographical area that supports malaria transmission, where the local Anopheles population sustains the basic reproductive rate (R0; average number of secondary infections arising in a susceptible population as a result of a single...

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Published in:	PLoS medicine Vol. 9; no. 1; p. e1001165
Main Authors:	Bousema, Teun, Griffin, Jamie T, Sauerwein, Robert W, Smith, David L, Churcher, Thomas S, Takken, Willem, Ghani, Azra, Drakeley, Chris, Gosling, Roly
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-01-2012 Public Library of Science (PLoS)
Subjects:	anopheles-gambiae Control control programs Disease Eradication Disease transmission Epidemiology Households Humans Immunization infection Infections Malaria Malaria - epidemiology Malaria - prevention & control Malaria - transmission Management Medical research Medicine Mosquito Control Mosquitoes plasmodium-falciparum Policy Forum Population Prevention Risk factors rural area Sanitation, Household transmission urban malaria vector populations west-africa young-children United States Disease Eradication Malaria Mosquito Control Humans
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Summary:	In more academic terms, an active focus of malaria transmission is a geographical area that supports malaria transmission, where the local Anopheles population sustains the basic reproductive rate (R0; average number of secondary infections arising in a susceptible population as a result of a single individual with malaria over the course of their malaria infection) at a level above 1 [16].\n The most inclusive approach to clear infections in humans, including those that are present at densities below the detection limit of rapid diagnostic tests or microscopy [55] is to give mass drug administration (MDA) where a full therapeutic dose of drugs are administered to a population without prior screening. Because all age groups contribute to malaria transmission [57], VIMT may need to be administered to all age groups to see an impact.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 The Policy Forum allows health policy makers around the world to discuss challenges and opportunities for improving health care in their societies. Conceived and designed the experiments: TB JTG CD RG. Performed the experiments: TB JTG TSC. Analyzed the data: TB JTG TSC DLS AG. Contributed reagents/materials/analysis tools: JTG TSC AG. Wrote the first draft of the manuscript: TB CD RG. Contributed to the writing of the manuscript: TB JTG RWS DLS TSC WT AG CD RG. ICMJE criteria for authorship read and met: TB JTG RWS DLS TSC WT AG CD RG. Agree with manuscript results and conclusions: TB JTG RWS DLS TSC WT AG CD RG.
ISSN:	1549-1676 1549-1277 1549-1676
DOI:	10.1371/journal.pmed.1001165