Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation

Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation

The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers...

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Bibliographic Details
Published in:Npj viruses Vol. 2; no. 1
Main Authors: Port, Julia R., Yinda, Claude Kwe, Ruckel, Claire, Schulz, Jonathan E., Smith, Brian J., Shaia, Carl I., Munster, Vincent J.
Format: Journal Article
Language:English
Published: 16-01-2024
Online Access:Get full text
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Summary:The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.
ISSN:2948-1767
2948-1767
DOI:10.1038/s44298-023-00012-2