Germline Stem Cell Transplantation and Transgenesis

• Published in: Science (American Association for the Advancement of Science) Vol. 296; no. 5576; pp. 2174 - 2176
• Main Author: Brinster, Ralph L.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 21-06-2002; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Animals; Antibody diversity; Biological and medical sciences; Cell Differentiation; Cell Separation; Cell transplantation; Cells; Cells, Cultured; Cellular differentiation; Cryopreservation; Fundamental and applied biological sciences. Psychology; Germ cells; Humans; Individualized Instruction; Male; Males; Mammalian male genital system; Morphology. Physiology; Pregnancy; Reviews; Rodents; Seminiferous Tubules - cytology; Sertoli cells; Sertoli Cells - physiology; Somatic cells; Spermatogenesis; Spermatogonia - cytology; Spermatogonia - physiology; Stem Cell Transplantation; Stem cells; Stem Cells - physiology; Testes; Testis - cytology; Transduction, Genetic; Transgenes; Transplantation, Heterologous; Transplants & implants; Vertebrates: reproduction; United States; Transgenic animal; Transplantation; Germinal cell; Testicle; Male genital system; Stem cell
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1071607

The recently developed testis cell transplantation method provides a powerful approach to studying the biology of the male germline stem cell and its microenvironment, the stem cell niche. The technique also is being used to examine spermatogenic defects, correct male infertility, and generate transgenic animals.