Zytotoxische CD8+-T-Zellen im Alter: unterschätzte Killer?

Zytotoxische CD8+-T-Zellen im Alter: unterschätzte Killer?

Abstract Aging leads to various alterations in immune cell functions. Here, we report our surprising findings that despite immunosenescence, CD8 + T cells’ cytotoxic efficiency increases with age. The FRET-based apoptosis sensor pCasper, stably transfected into tumor cells, revealed fundamental chan...

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Bibliographic Details
Published in:Biospektrum Vol. 30; no. 4; pp. 395 - 398
Main Authors: Lis, Annette, Kaschek, Lea, Zöphel, Dorina
Format: Journal Article
Language:German
Published: 01-06-2024
Online Access:Get full text
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Summary:Abstract Aging leads to various alterations in immune cell functions. Here, we report our surprising findings that despite immunosenescence, CD8 + T cells’ cytotoxic efficiency increases with age. The FRET-based apoptosis sensor pCasper, stably transfected into tumor cells, revealed fundamental changes in the cytotoxic mechanisms. Antigen-specific CD8 + T cells from elderly OT-I mice shift from apoptotic to necrotic killers. This capability might affect cell-based immunotherapies in old age.
ISSN:0947-0867
1868-6249
DOI:10.1007/s12268-024-2213-y