Oncogenic mutations at the dimer interface of EGFR lead to formation of covalent homo-dimers and allosteric activation of the kinase domain: A mechanism which alters the selectivity profile of oncogenic EGFR

Oncogenic mutations at the dimer interface of EGFR lead to formation of covalent homo-dimers and allosteric activation of the kinase domain: A mechanism which alters the selectivity profile of oncogenic EGFR

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Bibliographic Details
Published in:Annals of oncology Vol. 30; p. v189
Main Authors: Buck, E., O’Connor, M., Flohr, A., Iacone, R., Nicolaides, T., Zhang, J., Mayweg, A.V., Epstein, D.M.
Format: Journal Article
Language:English
Published: 01-10-2019
Online Access:Get full text
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Description
ISSN:0923-7534
DOI:10.1093/annonc/mdz244.063