Etidronic Acid Promoted Sequential One‐Pot Strategy for the Synthesis of 1 H ‐Imidazo[1,2‐ b ]pyrazoles: A Green Catalyst for Groebke‐Blackburn‐Bienaymé Reaction

• Published in: ChemistrySelect (Weinheim) Vol. 4; no. 38; pp. 11235 - 11238
• Main Authors: Vilapara, Kalpesh V., Gami, Sagar P., Gadara, Shobhna A., Naliapara, Yogesh T.
• Format: Journal Article
• Language: English
• Published: 17-10-2019
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.201902997

Abstract
A development of Groebke‐Blackburn‐Bienaymé (GBB) reaction was shown by the application of Etidronic acid as a green catalyst. A number of 1
H
‐imidazo[1,2‐
b
]pyrazoles derivatives were prepared via multicomponent GBB reaction in one pot sequential steps by the condensation of 5‐amino‐1
H
‐pyrazole, aldehyde and isonitrile. Here, we have demonstrated the development of GBB protocol by the utility of Etidronic acid in milder reaction medium to modify and simplify the existing synthetic strategies that removes hazardous acids, toxic solvents and drastic conditions with sustainable product yields and purity.