Many mutations in one clinical-trial basket

When abnormality in a gene is linked to cancer and a drug targets the encoded protein, how can the patients who will respond to the drug be identified if the gene is mutated in many different ways in many different cancers? When abnormality in a gene is linked to cancer and a drug targets the encode...

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Bibliographic Details
Published in:	Nature (London) Vol. 554; no. 7691; pp. 173 - 175
Main Author:	Mardis, Elaine
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08-02-2018 Nature Publishing Group
Subjects:	631/67 692/308 Cancer Cancer genetics Cancer therapies Clinical trials Genes Genetic aspects Genetic research Genomics Health aspects Humanities and Social Sciences Methods multidisciplinary Mutation News And Views Oncology, Experimental Patients Science Tumors United States Medical research Cancer
Online Access:	Get full text
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Summary:	When abnormality in a gene is linked to cancer and a drug targets the encoded protein, how can the patients who will respond to the drug be identified if the gene is mutated in many different ways in many different cancers? When abnormality in a gene is linked to cancer and a drug targets the encoded protein, how can the patients who will respond to the drug be identified if the gene is mutated in many different ways in many different cancers?
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 SourceType-Other Sources-1 ObjectType-News-1 content type line 66
ISSN:	0028-0836 1476-4687
DOI:	10.1038/d41586-018-01312-x