Diseases of the musculoskeletal system and connective tissue in relation to temporomandibular disorders—A SWEREG-TMD nationwide case-control study

• Published in: PloS one Vol. 17; no. 10; p. e0275930
• Main Authors: Salinas Fredricson, Adrian, Naimi-Akbar, Aron, Adami, Johanna, Lund, Bodil, Rosén, Annika, Hedenberg-Magnusson, Britt, Fredriksson, Lars, Krüger Weiner, Carina
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 12-10-2022; Public Library of Science (PLoS)
• Subjects: Biology and Life Sciences; Codes; Comorbidity; Complications and side effects; Connective tissue; Connective tissues; Dental care; Dentistry; Diagnostic systems; Disorders; Facial pain; Health aspects; Health care policy; Health services; Inflammation; Jaws; Medical diagnosis; Medicin och hälsovetenskap; Medicine and Health Sciences; Mental health; Musculoskeletal diseases; Musculoskeletal system; Orofacial pain; Pain; Patients; People and places; Plastic surgery; Population; Population studies; Prevention; Risk analysis; Risk factors; Soft tissues; Statistical analysis; Temporomandibular joint disorders; Tissues; Variables; Sweden
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0275930

Temporomandibular disorders (TMD) are comprised by a heterogenous group of diagnoses with multifaceted and complex etiologies. Although diseases of the musculoskeletal system and connective tissue (MSD) have been reported as risk factors for developing TMD, no nationwide population-based registry studies have been conducted to investigate this possible link. The aim of this study was to investigate the association between MSD and TMD in a population-based sample using Swedish registry data, and to further investigate the difference in such association between patients diagnosed with TMD in a hospital setting and patients surgically treated for the condition. A significant association between MSD and the development of TMD was found for all diagnostic categories: arthropathies (OR 2.0, CI 1.9-2.0); systemic connective tissue disorders (OR 2.3, CI 2.1-2.4); dorsopathies (OR 2.2, CI 2.1-2.2); soft tissue disorders (OR 2.2, CI 2.2-2.3); osteopathies and chondropathies (OR 1.7, CI 1.6-1.8); and other disorders of the musculoskeletal system and connective tissue (OR 1.9, CI 1.8-2.1). The associations were generally much stronger for TMD requiring surgical treatment. The diagnostic group with the strongest association was inflammatory polyarthropathies, M05-M14 (OR 11.7, CI 8.6-15.9), which was seen in the ST2 group.