Temporal dynamics of gene expression in heat-stressed Caenorhabditis elegans
There is considerable insight into pathways and genes associated with heat-stress conditions. Most genes involved in stress response have been identified using mutant screens or gene knockdowns. Yet, there is limited understanding of the temporal dynamics of global gene expression in stressful envir...
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| Published in: | PloS one Vol. 12; no. 12; p. e0189445 |
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| Abstract | There is considerable insight into pathways and genes associated with heat-stress conditions. Most genes involved in stress response have been identified using mutant screens or gene knockdowns. Yet, there is limited understanding of the temporal dynamics of global gene expression in stressful environments. Here, we studied global gene expression profiles during 12 hours of heat stress in the nematode C. elegans. Using a high-resolution time series of increasing stress exposures, we found a distinct shift in gene expression patterns between 3-4 hours into the stress response, separating an initially highly dynamic phase from a later relatively stagnant phase. This turning point in expression dynamics coincided with a phenotypic turning point, as shown by a strong decrease in movement, survival and, progeny count in the days following the stress. Both detectable at transcriptional and phenotypic level, this study pin-points a relatively small time frame during heat stress at which enough damage is accumulated, making it impossible to recover the next few days. |
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| AbstractList | There is considerable insight into pathways and genes associated with heat-stress conditions. Most genes involved in stress response have been identified using mutant screens or gene knockdowns. Yet, there is limited understanding of the temporal dynamics of global gene expression in stressful environments. Here, we studied global gene expression profiles during 12 hours of heat stress in the nematode C. elegans. Using a high-resolution time series of increasing stress exposures, we found a distinct shift in gene expression patterns between 3-4 hours into the stress response, separating an initially highly dynamic phase from a later relatively stagnant phase. This turning point in expression dynamics coincided with a phenotypic turning point, as shown by a strong decrease in movement, survival and, progeny count in the days following the stress. Both detectable at transcriptional and phenotypic level, this study pin-points a relatively small time frame during heat stress at which enough damage is accumulated, making it impossible to recover the next few days. There is considerable insight into pathways and genes associated with heat-stress conditions. Most genes involved in stress response have been identified using mutant screens or gene knockdowns. Yet, there is limited understanding of the temporal dynamics of global gene expression in stressful environments. Here, we studied global gene expression profiles during 12 hours of heat stress in the nematode C . elegans . Using a high-resolution time series of increasing stress exposures, we found a distinct shift in gene expression patterns between 3–4 hours into the stress response, separating an initially highly dynamic phase from a later relatively stagnant phase. This turning point in expression dynamics coincided with a phenotypic turning point, as shown by a strong decrease in movement, survival and, progeny count in the days following the stress. Both detectable at transcriptional and phenotypic level, this study pin-points a relatively small time frame during heat stress at which enough damage is accumulated, making it impossible to recover the next few days. |
| Audience | Academic |
| Author | Riksen, Joost A G Allesina, Stefano Rodriguez, Miriam Bevers, Roel P J Jovic, Katharina Grilli, Jacopo Sterken, Mark G Snoek, L Basten Kammenga, Jan E |
| AuthorAffiliation | 2 Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America 1 Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands INSERM U869, FRANCE |
| AuthorAffiliation_xml | – name: 2 Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America – name: 1 Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands – name: INSERM U869, FRANCE |
| Author_xml | – sequence: 1 givenname: Katharina orcidid: 0000-0002-9145-5953 surname: Jovic fullname: Jovic, Katharina organization: Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands – sequence: 2 givenname: Mark G surname: Sterken fullname: Sterken, Mark G organization: Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands – sequence: 3 givenname: Jacopo surname: Grilli fullname: Grilli, Jacopo organization: Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America – sequence: 4 givenname: Roel P J surname: Bevers fullname: Bevers, Roel P J organization: Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands – sequence: 5 givenname: Miriam surname: Rodriguez fullname: Rodriguez, Miriam organization: Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands – sequence: 6 givenname: Joost A G surname: Riksen fullname: Riksen, Joost A G organization: Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands – sequence: 7 givenname: Stefano surname: Allesina fullname: Allesina, Stefano organization: Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America – sequence: 8 givenname: Jan E surname: Kammenga fullname: Kammenga, Jan E organization: Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands – sequence: 9 givenname: L Basten surname: Snoek fullname: Snoek, L Basten organization: Laboratory of Nematology, Wageningen University, Wageningen, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29228038$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Jovic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Jovic et al 2017 Jovic et al Wageningen University & Research |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Jovic et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Jovic et al 2017 Jovic et al – notice: Wageningen University & Research |
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| Title | Temporal dynamics of gene expression in heat-stressed Caenorhabditis elegans |
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