Myo1e impairment results in actin reorganization, podocyte dysfunction, and proteinuria in zebrafish and cultured podocytes

Podocytes serve as an important constituent of the glomerular filtration barrier. Recently, we and others identified Myo1e as a key molecular component of the podocyte cytoskeleton. Myo1e mRNA and protein was expressed in human and mouse kidney sections as determined by Northern blot and reverse tra...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 8; p. e72750
Main Authors:	Mao, Jianhua, Wang, Dayan, Mataleena, Parikka, He, Bing, Niu, Dadi, Katayama, Kan, Xu, Xiangjun, Ojala, Juha Rm, Wang, Wenjing, Shu, Qiang, Du, Lizhong, Liu, Aimin, Pikkarainen, Timo, Patrakka, Jaakko, Tryggvason, Karl
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19-08-2013 Public Library of Science (PLoS)
Subjects:	Actin Actins - metabolism Animals Biochemistry Biology Biophysics Cell Count Cell migration Cell Migration Assays Cell Proliferation Cell Shape Cell size Cells, Cultured Cysts Cytoskeleton Cytoskeleton - metabolism Danio rerio DNA polymerases Down-Regulation Edema Endocytosis Fertilization Filtration Fluorescein-5-isothiocyanate - metabolism Gene Knockdown Techniques Hospitals Humans Immunofluorescence Impairment Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Glomerulus - metabolism Kidneys Kinases Larvae Medicin och hälsovetenskap Medicine Mice Muscle proteins Myosin Type I - metabolism Myosins - metabolism Nephrology Podocytes - metabolism Proteins Proteinuria Proteinuria - metabolism RNA RNA-directed DNA polymerase Rodents Transferrin - metabolism Zebrafish Zebrafish - metabolism Zebrafish Proteins - metabolism Sweden China
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