The relationship between levels of apolipoprotein A1 and B in aqueous and serum with stage of diabetic retinopathy

• Published in: Journal of health sciences and medicine : (Turkey) Vol. 6; no. 2; pp. 546 - 551
• Main Authors: ERBAHÇECİ TİMUR, İnci Elif, ÖRNEK, Kemal, ÇAĞLAYAN, Osman
• Format: Journal Article
• Language: English
• Published: 27-03-2023
• ISSN: 2636-8579; 2636-8579
• DOI: 10.32322/jhsm.1253299

Aim: To determine the association between serum and aqueous apolipoprotein (Apo) A1 and Apo B levels and Apo B/A1 ratio in diabetic retinopathy.
Material and Method: This cross-sectional prospective study included 63 diabetic patients with or without retinopathy and 38 control subjects who underwent cataract surgery. The study groups were as follows; healthy subjects (Group 1), diabetic patients without retinopathy (Group 2), with non-proliferative diabetic retinopathy (Group 3), and with proliferative diabetic retinopathy (Group 4). Serum and aqueous Apo A1 and Apo B levels were determined by using an enzyme-linked immunosorbent assay.
Results: The amount of Apo B was determined in aqueous samples of all (100%) patients in Group 4 and 77.7% of patients in Group 3.The mean serum Apo B/A1 ratio was significantly higher in Group 2, Group 3 and Group 4 compared with Group 1 (p=0.002, p=0.037 and p